Leading a church is a strenuous undertaking. It is not uncommon, for example, for the pastor to have physical symptoms that correspond to the ills of the church. In our case, my spouse suffered from neck and shoulder pain at one church. (He was literally carrying the church or so his body thought.) At another church he suffered from lower back pain. (That was the church where he was stabbed in the back by staff persons.) At another church he suffered from headaches. (Guess what caused those?)
The church where we currently serve is actually pretty healthy, so what ails him is pretty much normal aches and pains, but he did start having a few heart issues. This church has a real heart for mission and those who are hurting in the community. So perhaps there is a connection.
Serving a church is risky to your health. Pastors and us as families, see the very best people can be but also see the worst. We live in a sin-sick world and serve in a hospital for sinners; i.e., the church. Sickness spreads and a church can sap the pastor dry--leading to depression, which is rampant among clergy. But it can also lead to outbreaks of violence. Pastors and their families are not immune to emotional and physical abuse.
So what do we do? First, be aware. Second, make sure your spouse takes care of themselves with healthy eating, exercise, some down time, and some family fun. But often even those things will not be enough. The sicker the church, the more hours a pastor works and the more draining it in on the soul. So, encourage your spouse (and yourself) to seek out friends (email and Facebook are great for this) but also an area of their life where they can feel successful and appreciated. This may be a hobby or something else. Prayer is helpful too, but I promise God will direct you to take care of yourself. God loves pastors and their families too.